FMF is a periodic fever syndrome characterized by recurrent bouts of fever with accompanying pain. It is inherited and usually becomes apparent before 30 years of age.
It is most prevalent in the eastern Mediterranean region occurring with a frequency of 1-5 cases per 10,000 people. From a worldwide perspective, it is a rare disease.
FMF flares lasting from a few hours to 3 or 4 days can involve the following symptoms:
FMF flares can occur spontaneously or be triggered by physical or emotional stress, the menstrual cycle, or diet.
Possible symptoms of FMF
If FMF is untreated, repeated attacks may result in amyloidosis, a condition in which protein builds up in the kidneys and causes kidney damage.
FMF is an inherited disorder caused by gene mutations; a person is at risk of having FMF only if they inherited the gene mutation on chromosomes received from both parents.
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